Sébastien Rigali

Research Associate FRS_FNRS

Detailed information

Publication list

Research interest

  • Streptomyces biology
  • Bacterial development
  • Regulatory networks
  • Cave microbiology
  • Carbon source utilization and regulation
  • Plant-pathogen interactions

Research summary

Streptomyces Genetics and Development

Our studies mainly focus on the molecular mechanisms associated with the biology of Streptomyces species. Our aim is to unveil how these bacteria sense and respond to environmental signals in order to trigger their developmental program which includes antibiotics and other metabolite production concomitantly to the onset of morphogenesis. Next to the model species for developmental studies Streptomyces coelicolor, we also started investigations on Streptomyces scabies, the plant pathogen responsible for the common scab disease on root and tuber crops. Finally, in our search for novel antibiotic-producing actinobacteria we generated a unique collection of karstic isolates. Besides the identification of the metabolites they produce with potential interest in human therapy, we try to understand how these plant saprophytes have evolved to adapt their development to inorganic and oligotrophic environments.

More information on our research studies is available on Streptomyces Genetics and Development website

Lab members

  • Elodie Tenconi (Postdoc)
  • Aymeric Naomé (Postdoc)
  • Samuel Jourdan (PhD student)
  • Marta Maciejewska (PhD student)
  • Loïc Martinet (PhD student)
  • Delphine Adam (Master student)

Selected publications

  1. Jourdan S, Francis IM, Kim M, Salazar J, Planckaert S, Frère JM, Matagne A, Kerff F, Devreese B, Loria R, Rigali S. (2016) The CebE/MsiK transporter is a doorway to the cello-oligosaccharide-mediated induction of Streptomyces scabies pathogenicity. Scientific Reports. 6:27144.
  1. Francis IM, Jourdan S, Fanara S, Loria R, Rigali S. (2015) The cellobiose sensor CebR is the gatekeeper of Streptomyces scabies pathogenicity. MBio., 6:e02018.
  1. Rigali S, Nivelle R, Tocquin P. (2015) On the necessity and biological significance of threshold-free regulon prediction outputs. Mol Biosyst.11:333-7.
  1. Lambert S, Traxler MF, Craig M, Maciejewska M, Ongena M, van Wezel GP, Kolter R, Rigali S. (2014) Altered desferrioxamine-mediated iron utilization is a common trait of bald mutants of Streptomyces coelicolor. Metallomics. 6:1390-9.
  1. Rigali S, Titgemeyer F, Barends S, Mulder S, Thomae AW, Hopwood DA, van Wezel GP (2008) Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces. EMBO Rep. 9:670-5.